H2020-872570-KYKLOS 4.0 (https://kyklos40project.eu/): KYKLOS4.0 will demonstrate, in a realistic, measurable, and replicable way the transformative effects that CPS, PLM, LCA, AR and AI technologies and methodologies will have to the Circular Manufacturing (CM) Framework. To this end, KYKLOS 4.0 will (1) perform large-scale piloting in 7 pilots to demonstrate the technical, environmental and economic viability of KYKLOS 4.0 Ecosystem to reshape intra-factory processes and services, (2) show KYKLOS 4.0 value in terms of operational efficiency improvements by at least 15%, (3) deliver resources reusable solutions (second use of material, part and components reuse) for the whole manufacturing sectors, (4) ensure scalability for future scale of novel CM technologies and services at least at the level of year 2024, (5) engage over 100 key European industry actors, (through open calls and workshops) (6) transfer knowledge and technology to increase use of KYKLOS 4.0 Ecosystem to at least 50%, (7) strengthen the position of EU CM technologies providers and sector fostering a market share of up to 12% (8) pursue a strong plan for sustainability by incubating at least 3 post-project replication sites, (9) mobilize additional sector investments of at least 6 times the EC contribution.